Compounds
What each compound is, what it does to a growth plate, and what it does to the rest of you. Members read every page in full.
Hormones
What the rest of the body tells the growth plate.
Somatropin
Approved for a growth disorder
Lonapegsomatropin
SkytrofaApproved for a growth disorder
Somatrogon
NgenlaApproved for a growth disorder
Somapacitan
SogroyaApproved for a growth disorder
Sermorelin
Withdrawn or never marketed
Tesamorelin
EgriftaApproved, for something else
CJC-1295
Not approved for people anywhere
MK-677
ibutamorenIn human trials
Macimorelin
MacrilenApproved, for something else
Anamorelin
Approved, for something else
Ipamorelin
Not approved for people anywhere
Pralmorelin
GHRP-2Approved, for something else
Tabimorelin
Withdrawn or never marketed
Ruxolitinib
Jakafi, OpzeluraApproved, for something else
Tofacitinib
XeljanzApproved, for something else
Baricitinib
OlumiantApproved, for something else
Upadacitinib
RinvoqApproved, for something else
Efruxifermin
In human trialsPegozafermin
In human trials
Mecasermin
IncrelexApproved for a growth disorderMecasermin rinfabate
IPLEXWithdrawn or never marketedPAPP-A2 protein
rhPAPP-A2Animals onlySTC2 antibodies
Cells and tissue only
Levothyroxine
T4Approved, for something else
Liothyronine
T3, CytomelApproved, for something else
Resmetirom
RezdiffraApproved, for something else
Sobetirome
GC-1Not approved for people anywhere
Cinacalcet
SensiparApproved, for something else
Etelcalcetide
ParsabivApproved, for something elseBurosumab
CrysvitaApproved for a growth disorder
Oral phosphate plus calcitriol
In human trialsAsfotase alfa
StrensiqApproved for a growth disorder
Palovarotene
SohonosApproved, for something else
Isotretinoin
Approved, for something else
Fenretinide
In human trials
Tamibarotene
Amnolake, Am80Approved, for something else
AM580
CD336, Ro 40-6055Not approved for people anywhere
CD2665
Cells and tissue only
Mifepristone
KorlymApproved, for something else
Relacorilant
Approved, for something elseTocilizumab
ActemraApproved, for something else
Infliximab
RemicadeApproved, for something else
Adalimumab
HumiraApproved, for something elseCanakinumab
IlarisApproved, for something else
Anakinra
KineretApproved, for something else
Etanercept
EnbrelApproved, for something else
Curcumin
Food or supplement
Celastrol
Not approved for people anywhereNF-κB relay inhibitors
Cells and tissue only
MCC950 and TAK-242
Not approved for people anywhere
Diacerein
Approved, for something else
Omega-3
DHA and EPAFood or supplement
Glycyrrhizin
Food or supplementSecukinumab / Ixekizumab
Approved, for something elseAdipoRon
Animals onlyPioglitazone / Rosiglitazone
Approved, for something else
Melatonin
Food or supplement
Magnesium
Food or supplement
Glycine
Food or supplement
L-theanine
Food or supplement
Ashwagandha
Food or supplement
Tart cherry
Food or supplement
Tryptophan
Food or supplement
Diphenhydramine
Approved, for something else
Timing
What starts puberty, and what closes the plates.
Elagolix
Approved, for something elseKisspeptin-54
In human trials
MVT-602
In human trials
Letrozole / Anastrozole
Approved, for something else
Exemestane
Approved, for something else
Raloxifene
EvistaApproved, for something else
Bazedoxifene
in DuaveeApproved, for something else
Tamoxifen
Approved, for something else
Toremifene
FarestonApproved, for something else
Endoxifen
Approved, for something else
Oxandrolone
Withdrawn or never marketed
Nandrolone decanoate
Approved, for something else
Trenbolone
Not approved for people anywhere
Icariin
Food or supplement
Inside the plate
Signals the plate’s own cells pass to each other.
Abaloparatide
TymlosApproved, for something else
Teriparatide
Approved, for something elsePTHrP(1–34)
Cells and tissue onlyPTH1R inverse agonists
Animals only
SAG
Cells and tissue only
Purmorphamine
Cells and tissue only
SAG 21k
Hedgehog agonist 1Animals only
GANT61
Cells and tissue only
Pterosin B
Animals only
Pentoxifylline
Approved, for something else
Vosoritide
Voxzogo, BMN-111Approved for a growth disorderNavepegritide
Yuviwel, TransCon CNPApproved for a growth disorder
Sacubitril
sacubitril/valsartan, EntrestoApproved, for something else
Sildenafil / Tadalafil / Vardenafil / Avanafil / Udenafil / Mirodenafil
Approved, for something else
Riociguat / Vericiguat
Approved, for something else
BAY 41-2272
Cells and tissue only
8-Br-cGMP / Sp-8-Br-PET-cGMPS / PET-cGMP
Cells and tissue only
LB-100
In human trials
Cilostazol
Approved, for something else
Erdafitinib / Pemigatinib / Futibatinib
Approved, for something else
AZD4547
Not approved for people anywhere
Infigratinib
BGJ398In human trials
TYRA-300
dabogratinibIn human trials
Vepugratinib
LOXO-435, LY3866288In human trials
Ponatinib
Approved, for something else
Derazantinib
Not approved for people anywhere
PD98059 / U0126
Animals only
Meclizine
Approved, for something elseVofatamab
B-701In human trials
Statins
Approved, for something elseRBM-007
umedaptanib pegolIn human trialsRecifercept
TA-46Withdrawn or never marketed
rhBMP-2
Approved, for something else
rhBMP-7
OP-1Withdrawn or never marketedrhBMP-4 / rhBMP-6
Animals onlySotatercept and Luspatercept
ACE-011 and ACE-536Approved, for something else
SB-431542 / A-83-01
Cells and tissue onlyCM10
Cells and tissue onlyCK2.1
Cells and tissue only
GDF-5
CDMP-1Not approved for people anywhereGDF-6
CDMP-2Not approved for people anywhere
BMP-9
GDF-2Cells and tissue onlyBMP-2/7 heterodimer
Cells and tissue only
Tacrolimus
FK506Approved, for something else
Recombinant TGF-β1, β2 and β3
Cells and tissue onlyAvotermin
JuvistaWithdrawn or never marketedTissueGene-C
InvossaWithdrawn or never marketed
Platelet-rich plasma
Not approved for people anywhere
Autologous conditioned serum
OrthokineNot approved for people anywhereLink-N
Cells and tissue onlyMSC exosomes
Not approved for people anywhereRomosozumab
EvenityApproved, for something elseBlosozumab
Withdrawn or never marketedSetrusumab
UX143In human trialsDKN-01
sirexatamabIn human trials
WAY-262611
Animals only
WAY-316606
Cells and tissue onlyKY19382
Animals only
Tankyrase inhibitors
XAV939, IWR-1Cells and tissue only
Lorecivivint
SM04690In human trialsCB-103
In human trialsIbuprofen / Naproxen
Approved, for something elseIndomethacin
Approved, for something elseCelecoxib
CelebrexApproved, for something elseAlprostadil
Prostin VR PediatricApproved, for something else
Nutritional repletion
Food or supplement
Glucocorticoid withdrawal
Approved, for something else
GnRH analogues
Approved, for something else
FOXO4-DRI
Cells and tissue only
Quercetin
Food or supplement
Epitalon
Not approved for people anywhere
Cartalax
Not approved for people anywhere
N-acetylcysteine
Approved, for something elseNACET
Not approved for people anywhere
Sulforaphane
Food or supplement
Grape seed proanthocyanidins
Food or supplement
Apigenin
Food or supplement
Taurine
Food or supplement
EGCG
Food or supplement
Chlorogenic acid
Food or supplement
MitoQ and coenzyme Q10
Food or supplement
PQQ
Food or supplement
Elamipretide
Approved, for something else
Astaxanthin
Food or supplement
Alpha-lipoic acid
Food or supplement
Inside the cell
What a cartilage cell does once a signal arrives.
Nirogacestat
OgsiveoApproved, for something else
DAPT
Animals onlymiR-140
Animals onlymiR-199a*
Cells and tissue only
Ellipticine
Cells and tissue only
A-674563
Cells and tissue only
Simvastatin
Approved, for something else
Clodronate
Approved, for something else
Vorinostat
SAHAApproved, for something else
Trichostatin A
Cells and tissue only
Entinostat
MS-275Approved, for something else
Valproate
Approved, for something else
Fibrates
ciprofibrate, fenofibrate, bezafibrateApproved, for something else
Bexarotene
Approved, for something else
Kartogenin
Animals only
Mocetinostat
In human trialsKA34
In human trials
TD-198946
Cells and tissue only
MHY1485
Cells and tissue only
NV-5138
mefluleucineIn human trials
L-Leucine
Food or supplement
NMN and nicotinamide riboside
Food or supplement
Nicotinamide
Food or supplement
Resveratrol
Food or supplement
SRT1720 and SRT2104
Not approved for people anywhere
Pterostilbene and piceatannol
Food or supplement
Fisetin
Food or supplement
Metformin
Approved, for something else
AICAR
Not approved for people anywhere
Rapamycin
sirolimusApproved, for something else
Spermidine
Food or supplement
Trehalose
Food or supplement
Urolithin A
Food or supplement
EGF
Cells and tissue onlyRecombinant TGF-α
Cells and tissue onlyCiclosporin
CyclosporineApproved, for something else
CHIR99021
Cells and tissue only
SB-216763 / SB-415286
Cells and tissue only
Tideglusib
NP-12In human trials
TDZD-8
Cells and tissue only
Lithium
Approved, for something else
Bikinin
Cells and tissue only
KMN-159
Animals only
Indirubin-3'-oxime
Animals only
BIO
6-bromoindirubin-3'-oximeCells and tissue onlyMETTL3 complex activators
Selberg seriesCells and tissue only
Isoborneol
Animals onlyERK and USP5
Cells and tissue only
Exercise
Animals onlyHIF-1α stabilisers
Approved, for something else
Tazemetostat
TazverikWithdrawn or never marketed
BIX-01294
Cells and tissue onlyJQ1
Animals only
Y-27632
Cells and tissue only
Fasudil
Approved, for something else
GSK1016790A
Cells and tissue only
Yoda1
Cells and tissue only
SC79
Cells and tissue only
Cytochalasin D
Cells and tissue only
Mechanical loading
Animals only
Extracorporeal shockwave therapy
Approved, for something else
Low-intensity pulsed ultrasound
Approved, for something else
Low-level laser therapy
Approved, for something else
Matrix and bone
What the plate is built from, and how it becomes bone.
PAPS
Cells and tissue only2-N,6-O sulfated chitosan
26SCSAnimals only
Glucosamine
Food or supplement
Polygonatum sibiricum polysaccharide
Food or supplement
Salidroside
Food or supplement
Vindoline
Cells and tissue onlyLDQN-C and JJYMD-C
Cells and tissue only
Carbamazepine
Tegretol, EquetroApproved, for something elseINZ-701
BMN 401Withdrawn or never marketed
Roxadustat
Approved, for something else
Daprodustat
Withdrawn or never marketed
Vadadustat
Approved, for something else
IOX2 / DMOG
Animals onlyBevacizumab
Approved, for something else
Recombinant VEGF165
Cells and tissue onlyImatinib
GleevecApproved, for something elseDenosumab
Prolia, XgevaApproved, for something elsePamidronate / Zoledronate
Approved, for something elseOdanacatib
MK-0822Withdrawn or never marketed
BGB324
bemcentinibIn human trials
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