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Infliximab

Hormones · In Inflammation and growth failure

3D structure of three infliximab binding arms holding a TNF-alpha trimer (PDB 4G3Y)
Structure: three infliximab binding arms holding a TNF-alpha trimer. Image from the RCSB PDB (RCSB.org) of PDB ID 4G3Y (Liang et al., 2013)

Approved, for something elseHeight measured in peopleBy injectionAntibodyAlso Remicade

An antibody drip that blocks an inflammation signal, licensed for Crohn's disease in children from six.

Chimeric monoclonal antibody against TNF-α, given by intravenous infusion. Approved for paediatric Crohn's disease in patients 6 years of age and older with moderately to severely active disease after inadequate response to conventional therapy.

FDA label

Risks. Its label carries the strongest class of warning for serious infection and for cancer, including a rare aggressive lymphoma that has killed people and whose reported cases were mostly teenage and young adult men with bowel disease.

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