NV-5138
In human trialsMeasured in people, not heightBy mouthSmall moleculeAlso mefluleucine
A pill that imitates the amino acid the cell's growth sensor reads as a sign of food, built to work in the brain.
Orally available small molecule that binds Sestrin2 and activates mTORC1 through the leucine-sensing arm. Designed for the brain, where leucine itself is a poor mTORC1 activator because it is consumed as a metabolic precursor before it can signal. Carried into human trials as SPN-820.
Risks. In its depression trial, side effects were much like placebo, mostly nausea and dizziness, and the trial failed. It has only been given to adults.
On this page
- At the growth plate, members only
- Risks and side effects, members only
The rest of this page is for members
What has been measured, in whom, with every source, and what it does to the rest of you. And every article in the library.
Join for $11.99Lifetime · 3 of 10 founding spots left
Tax is added at checkout (VAT/GST where it applies).
Renews every month at the current price plus tax until you cancel. Cancel from your account before the next monthly charge to stop it.
Card purchases are sold and charged by Link (Stripe) under Link's terms and refund policy.
Already a member? Sign in
Educational content, not medical advice. Nothing here is a recommendation to take or stop taking anything — talk to a doctor about your own situation.