GSK1016790A

Inside the cell · In Cell shape and mechanical load

Chemical structure of GSK1016790A
Structure: GSK1016790A, PubChem CID 23630211

Cells and tissue onlyNot measured in peopleResearch onlySmall molecule

A laboratory chemical that opens the channel cartilage cells use to feel pressure, faking the signal that loading produces.

A potent TRPV4 agonist that reproduces the calcium signal generated by loading. A research reagent.

Risks. Switching these channels on throughout the body makes blood vessels leak, which is why the class has not been used as medicine.

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What has been measured, in whom, with every source, and what it does to the rest of you. And every article in the library.

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Educational content, not medical advice. Nothing here is a recommendation to take or stop taking anything — talk to a doctor about your own situation.