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Adalimumab

Hormones · In Inflammation and growth failure

3D structure of an adalimumab binding arm holding TNF-alpha (PDB 3WD5)
Structure: an adalimumab binding arm holding TNF-alpha. Image from the RCSB PDB (RCSB.org) of PDB ID 3WD5 (Hu et al., 2013)

Approved, for something elseHeight measured in peopleBy injectionAntibodyAlso Humira

An injected antibody that blocks an inflammation signal, licensed for Crohn's disease from age six and childhood arthritis from age two.

Fully human monoclonal antibody against TNF-α, given subcutaneously. Approved for moderately to severely active Crohn's disease in adults and children 6 years of age and older, and for polyarticular JIA from 2 years.

FDA label

Risks. Its label carries the strongest class of warning for serious infection and for cancer in children and teenagers, including a rare aggressive lymphoma, and it is approved from the age of two.

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