GANT61

Inside the plate · In Hedgehog signalling and the PTHrP loop

Chemical structure of GANT61
Structure: GANT61, PubChem CID 421610

Cells and tissue onlyNot measured in peopleResearch onlySmall molecule

A research chemical that blocks the last step of the Hedgehog signal, where it switches genes on.

A GLI inhibitor and antitumour research tool, built to shut Hedgehog transcription down. It binds GLI1 between zinc fingers 2 and 3, at sites conserved in GLI2, and blocks GLI1- and GLI2-mediated transcription.

Oncotarget, 2014PNAS, 2007

Risks. No safety information in people, and it falls apart in water into the piece that does the actual blocking.

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