Lorecivivint
In human trialsMeasured in people, not heightBy injectionSmall moleculeAlso SM04690
A drug injected into an arthritic knee that turns the Wnt pathway down a little, by blocking two enzymes rather than the pathway itself. Not approved anywhere.
An inhibitor of two kinases, CLK2 and DYRK1A, which changes how Wnt pathway components are spliced and produces a moderate reduction in signalling without acting on β-catenin directly. Injected into the knee joint, developed for osteoarthritis, and not approved anywhere.
Risks. Side effects were much like placebo. The early trial had one serious event, a racing heart, and injecting anything into a joint carries a risk of infection on its own.
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