Spermidine

Inside the cell · In Sirtuins and autophagy

Chemical structure of Spermidine
Structure: Spermidine, PubChem CID 1102

Food or supplementMeasured in people, not heightBy mouthNutrient

A compound found in wheat germ and aged cheese, sold as a supplement that switches on the cell’s clean-up system.

A polyamine present in wheat germ, soy and aged cheese, sold as a wheat-germ extract. It induces autophagy by inhibiting the acetyltransferase EP300.

Risks. A genetic condition that leaves people with a permanently high spermidine ratio causes weak bones and short stature. In a dish it speeds cartilage cells through their final step, which uses the growth plate up.

On this page

  • At the growth plate, members only
  • Risks and side effects, members only

The rest of this page is for members

What has been measured, in whom, with every source, and what it does to the rest of you. And every article in the library.

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Educational content, not medical advice. Nothing here is a recommendation to take or stop taking anything — talk to a doctor about your own situation.