SB-216763 / SB-415286
Cells and tissue onlyNot measured in peopleResearch onlySmall molecule
Two laboratory chemicals that block GSK3 and almost nothing else, which is why researchers still use them.
Structurally distinct maleimides from the same programme, ATP-competitive rather than substrate-competitive — they occupy the ATP pocket like CHIR99021 does. Selective, with no meaningful inhibition across a panel of 24 other kinases, which is why they are still the reference tools.
Risks. There is no safety information for them in people, and the enzyme they block is used by many other processes in the body.
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What has been measured, in whom, with every source, and what it does to the rest of you. And every article in the library.
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Educational content, not medical advice. Nothing here is a recommendation to take or stop taking anything — talk to a doctor about your own situation.