Clodronate
Approved, for something elseMeasured in people, not heightBy mouthSmall molecule
An older bone drug given for bone damage in cancer, approved across Europe and Canada but not in the United States.
A first-generation bisphosphonate without nitrogen in it, approved in the UK, Canada, Australia and much of Europe for bone pain and bone destruction in cancer, and not approved in the United States for people. Unlike the nitrogen-containing bisphosphonates it works by being converted inside cells into a non-hydrolysable ATP analogue.
Risks. Jaw bone death, unusual thigh fractures, kidney and gut damage. It is not established as safe in children, and it stays locked in the skeleton for years, leaving visible lines in growing bone.
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- Risks and side effects, members only
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What has been measured, in whom, with every source, and what it does to the rest of you. And every article in the library.
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Educational content, not medical advice. Nothing here is a recommendation to take or stop taking anything — talk to a doctor about your own situation.