Resveratrol

Inside the cell · In Sirtuins and autophagy

Chemical structure of Resveratrol
Structure: Resveratrol, PubChem CID 445154

Food or supplementMeasured in people, not heightBy mouthNutrient

A compound from grape skin. Whether it really switches SIRT1 on has been argued over for fifteen years.

A stilbene from grape skin, sold as a supplement. Whether it activates SIRT1 directly has been disputed since the apparent activation was traced to a fluorescent tag on the test substrate; a later paper argued the activation is real but needs particular bulky residues. In cells much of its effect appears indirect, through phosphodiesterase inhibition raising AMPK.

J Biol Chem, 2010Science, 2013

Risks. Its trials in people are mixed, and the way it worked in rabbits may be an oestrogen effect, which is the signal that ends growth.

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What has been measured, in whom, with every source, and what it does to the rest of you. And every article in the library.

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Educational content, not medical advice. Nothing here is a recommendation to take or stop taking anything — talk to a doctor about your own situation.