Celastrol
Not approved for people anywhereNot measured in peopleBy mouthSmall molecule
A compound from thunder god vine root. Not approved anywhere, though preparations of the whole plant are sold in China.
A triterpenoid from the root bark of thunder god vine, which inhibits IKKβ and disrupts the HSP90 chaperone complex. Celastrol itself is approved nowhere, though whole-plant preparations are marketed in China for rheumatoid arthritis.
Risks. Its effect on the heart appears at lower amounts than the effect it is taken for. It also makes animals eat less, which by itself would stunt a growing child.
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What has been measured, in whom, with every source, and what it does to the rest of you. And every article in the library.
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Educational content, not medical advice. Nothing here is a recommendation to take or stop taking anything — talk to a doctor about your own situation.