STC2 antibodies

Hormones · In IGF bioavailability

Cells and tissue onlyNot measured in peopleResearch onlyAntibody

A drug that would block the off-switch on the enzyme that frees IGF-1, which does not exist for people and has never had a trial registered.

Antibodies against stanniocalcin-2, the protein that binds PAPP-A covalently and jams it. Blocking the inhibitor would free the protease, the pharmacological version of the rare human STC2 variants. Not approved and not in trials: no registered study of any stanniocalcin drug exists, for growth or otherwise.

J Biol Chem, 2015

Risks. Nothing has ever been tested in a person, so nothing is known about its safety.

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