Letrozole / Anastrozole
Approved, for something elseHeight measured in peopleBy mouthSmall molecule
Two drugs that block the enzyme turning testosterone into oestrogen, both approved to treat breast cancer in older women.
Non-steroidal aromatase inhibitors. They bind the iron of the haem group in the aromatase active site, reversibly and competitively, and both are approved for hormone receptor-positive breast cancer in postmenopausal women.
Risks. Boys in the trials lost bone density and showed spinal abnormalities, with acne and mood changes alongside the testosterone rise, and the review that followed concluded these drugs should be used with restraint.
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