Sotatercept and Luspatercept
Approved, for something elseMeasured in people, not heightBy injectionProtein or enzymeAlso ACE-011 and ACE-536
Decoy proteins that soak up signals before they can reach their receptor.
Fusion proteins built from the extracellular part of an activin receptor — ActRIIA for sotatercept, a modified ActRIIB for luspatercept — attached to an antibody Fc. They mop up activins and related ligands before those reach a receptor.
Risks. Sotatercept can thicken the blood and cause bleeding; luspatercept can cause clots and high blood pressure, and is not for children after it caused blood cancers in young rats.
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Educational content, not medical advice. Nothing here is a recommendation to take or stop taking anything — talk to a doctor about your own situation.