RBM-007

Inside the plate · In FGF and FGFR3

In human trialsHeight measured in peopleBy injectionNucleic acidAlso umedaptanib pegol

An injected strand of nucleic acid that soaks up FGF2, one of the signalling molecules, before it can switch on the receptor that slows cartilage growth.

An oligonucleotide aptamer from RIBOMIC that binds FGF2 and stops it activating FGFR3. It targets FGF2, not FGF18 or FGF9. Given by subcutaneous injection.

Sci Transl Med

Risks. Injected into the eye in older adults, it caused no severe side effects. No journal has published results from its trials in children, and its growth claim comes from a press release with no placebo group.

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