SRT1720 and SRT2104

Inside the cell · In Sirtuins and autophagy

Chemical structure of Srt1720
Structure: Srt1720, one of the class, PubChem CID 25232708

Not approved for people anywhereMeasured in people, not heightBy mouthSmall molecule

Purpose-built drug versions of resveratrol, caught up, like it, in the dispute over whether they switch SIRT1 on at all.

Synthetic SIRT1 activators built to be more potent and more drug-like than resveratrol, and named in the same assay dispute that undermined resveratrol’s direct-activation claim.

J Biol Chem, 2010

Risks. Tolerated in adult trials but never approved for anything, and not available as a medicine. No child has ever taken either.

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