Ellipticine
Cells and tissue onlyNot measured in peopleResearch onlySmall molecule
A plant chemical studied against cancer, which damages DNA. It turned up in a search for anything that switches SOX9 on.
A plant alkaloid from Ochrosia elliptica studied as an anticancer agent. It intercalates DNA and poisons topoisomerase II, and the liver converts it into forms that bind covalently to DNA. It reached this library through a screen that used a Sox9 promoter driving a fluorescent reporter.
Risks. It damages DNA and is activated by the liver into something that sticks to DNA.
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