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Etanercept

Hormones · In Inflammation and growth failure

3D structure of TNF bound to TNF receptor 2, the receptor half of etanercept (PDB 3ALQ)
Structure: TNF bound to TNF receptor 2, the receptor half of etanercept. Image from the RCSB PDB (RCSB.org) of PDB ID 3ALQ (Mukai et al., 2010)

Approved, for something elseHeight measured in peopleBy injectionProtein or enzymeAlso Enbrel

A drug that acts as a sponge for TNF, soaking it up before it can act. Approved for children with arthritis from the age of two.

Not an antibody but a decoy receptor: the TNF-binding part of the p75 receptor fused to an antibody tail, which mops up TNF-α and lymphotoxin-α before they reach a cell. Given by subcutaneous injection, and approved for polyarticular juvenile idiopathic arthritis and juvenile psoriatic arthritis from two years of age.

label

Risks. A boxed warning for serious infections and for cancers including lymphoma in children.

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