Tankyrase inhibitors
Cells and tissue onlyNot measured in peopleResearch onlySmall moleculeAlso XAV939, IWR-1
Research chemicals that turn the cartilage-building signal down rather than up.
Two chemically unrelated small molecules that inhibit the enzymes tankyrase 1 and 2. Those enzymes tag axin for destruction, so inhibiting them stabilises axin, which is the limiting part of the complex that degrades β-catenin. The result is less Wnt signalling, not more.
Risks. In growing mice the class caused bone loss, and gut damage limits how much can be given.
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What has been measured, in whom, with every source, and what it does to the rest of you. And every article in the library.
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Educational content, not medical advice. Nothing here is a recommendation to take or stop taking anything — talk to a doctor about your own situation.