PTH1R inverse agonists
Animals onlyNot measured in peopleResearch onlyPeptide
Experimental peptides that switch a receptor off below its idle setting, made for a rare dwarfism caused by that receptor being stuck on.
Peptide inverse agonists of PTH1R, drugs that turn a receptor off below its resting level, built against the activating receptor mutations of Jansen metaphyseal chondrodysplasia. Preclinical only, and nothing in the class is approved.
Risks. It has never been given to a person, so there is no safety information.
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