Sildenafil / Tadalafil / Vardenafil / Avanafil / Udenafil / Mirodenafil

Inside the plate · In NPR2

Chemical structure of Sildenafil
Structure: Sildenafil, one of the six, PubChem CID 135398744

Approved, for something elseMeasured in people, not heightBy mouthSmall molecule

Erectile dysfunction and lung blood pressure drugs that stop a cell messenger being broken down.

PDE5 inhibitors. They block PDE5-mediated hydrolysis of cGMP, raising intracellular cGMP where PDE5 is the operative cGMP-degrading enzyme. They are erectile dysfunction and lung blood pressure drugs.

Risks. In the two trials of sildenafil in children, more of those on higher doses died — 22% on the highest against 9% on the lowest. The label puts that down to the disease rather than the drug.

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