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Efruxifermin

Hormones · In JAK2, STAT5B and GH resistance

3D structure of the core of FGF21, the hormone efruxifermin is built on (PDB 6M6E)
Structure: the core of FGF21, the hormone efruxifermin is built on. Image from the RCSB PDB (RCSB.org) of PDB ID 6M6E (Zhu et al., 2021)

In human trialsMeasured in people, not heightBy injectionProtein or enzyme

A copy of the fasting hormone FGF21, in late trials for fatty liver disease.

An Fc-FGF21 fusion protein, in the phase 3 SYNCHRONY programme for MASH. Not approved anywhere.

ClinicalTrials.gov

Risks. In the adult trials it mostly caused diarrhoea and nausea, and one person had a serious inflammation of the gullet put down to it. It has never been tried in children.

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What has been measured, in whom, with every source, and what it does to the rest of you. And every article in the library.

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Educational content, not medical advice. Nothing here is a recommendation to take or stop taking anything — talk to a doctor about your own situation.