A-674563
Cells and tissue onlyNot measured in peopleResearch onlySmall molecule
A laboratory chemical sold as an Akt blocker. It was the best hit when thousands of compounds were tested for switching cartilage genes on.
A kinase inhibitor sold as an Akt1 inhibitor, and the top hit from a screen of 5,822 compounds against a collagen XI reporter. Its selectivity is poor: in an unbiased panel of 442 kinases, Akt1 is only its eighteenth-tightest target.
Risks. Never given to a person, with no safety data. Mice without its target are smaller, and approved drugs that block the same thing commonly raise blood sugar.
On this page
- At the growth plate, members only
- Risks and side effects, members only
The rest of this page is for members
What has been measured, in whom, with every source, and what it does to the rest of you. And every article in the library.
Join for $11.99Lifetime · 3 of 10 founding spots left
Tax is added at checkout (VAT/GST where it applies).
Renews every month at the current price plus tax until you cancel. Cancel from your account before the next monthly charge to stop it.
Card purchases are sold and charged by Link (Stripe) under Link's terms and refund policy.
Already a member? Sign in
Educational content, not medical advice. Nothing here is a recommendation to take or stop taking anything — talk to a doctor about your own situation.