Tamibarotene
Approved, for something elseMeasured in people, not heightBy mouthSmall moleculeAlso Amnolake, Am80
A leukaemia tablet approved only in Japan, related to vitamin A.
A synthetic retinobenzoic acid that preferentially activates the retinoic acid receptor alpha, chemically more stable than all-trans retinoic acid and more potent at inducing differentiation in promyelocytic cells. Approved in Japan since 2005 as Amnolake for relapsed or refractory acute promyelocytic leukaemia, with no approval elsewhere.
Risks. A serious hospital drug: it causes birth defects, and a potentially fatal reaction in at least one patient in twenty.
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