Sacubitril
Approved, for something elseMeasured in people, not heightBy mouthSmall moleculeAlso sacubitril/valsartan, Entresto
A heart failure drug that blocks the enzyme which chops up CNP, the body's own signal for the NPR2 receptor, so more of it survives.
A neprilysin inhibitor, marketed only in fixed combination with the angiotensin II receptor blocker valsartan. Neprilysin is the enzyme that degrades CNP, so inhibiting it leaves more CNP to act on NPR2 without supplying any. FDA approved to reduce cardiovascular death and heart failure hospitalisation in adults with chronic heart failure, and for symptomatic heart failure with systemic left ventricular systolic dysfunction in paediatric patients aged 1 year and older. No skeletal indication.
Risks. It carries the strongest class of warning because it can injure and kill an unborn baby, along with warnings for dangerous swelling, low blood pressure, kidney damage and high potassium.
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Educational content, not medical advice. Nothing here is a recommendation to take or stop taking anything — talk to a doctor about your own situation.