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Anakinra

Hormones · In Inflammation and growth failure

3D structure of the interleukin-1 receptor antagonist, which anakinra is (PDB 1ILR)
Structure: the interleukin-1 receptor antagonist, which anakinra is. Image from the RCSB PDB (RCSB.org) of PDB ID 1ILR (Schreuder et al., 1995)

Approved, for something elseHeight measured in peopleBy injectionProtein or enzymeAlso Kineret

A lab-made copy of the body's own blocker for one inflammation signal, licensed in the US for adult arthritis and two rare newborn conditions.

Recombinant IL-1 receptor antagonist, given by subcutaneous injection. The US label covers rheumatoid arthritis in patients 18 years of age or older, neonatal-onset multisystem inflammatory disease, and deficiency of the interleukin-1 receptor antagonist. Systemic JIA is not a US indication.

FDA label

Risks. No boxed warning, but its label warns of serious infection, severe allergic reactions, amyloid deposits after long use, and white cell counts that need monitoring.

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