Imatinib
Approved, for something elseHeight measured in peopleBy mouthSmall moleculeAlso Gleevec
A leukaemia tablet, approved for children as well as adults, that blocks the PDGF receptor along with two other kinases.
A tyrosine kinase inhibitor of PDGFRα and PDGFRβ, and of BCR-ABL and KIT. Approved for newly diagnosed Philadelphia chromosome-positive chronic myeloid leukaemia in adults and children, and for eight further indications, among them the myelodysplastic and myeloproliferative diseases that carry PDGFR gene rearrangements.
Risks. No boxed warning, but its label warns of fluid retention, low blood counts, heart failure, liver damage that has been fatal, bleeding, and holes in the bowel. A section of that label is headed growth retardation in children and adolescents: slowed growth has been reported in children and pre-adolescents, the long-term effect of staying on it is unknown, and prescribers are told to measure growth.
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