Nirogacestat
Approved, for something elseMeasured in people, not heightBy mouthSmall moleculeAlso Ogsiveo
A tablet that blocks the final cut the Notch signal needs in order to work.
An oral γ-secretase inhibitor. γ-secretase makes the cut that frees the Notch intracellular domain, so blocking it blocks Notch at the last step.
Risks. Three-quarters of the women of childbearing age in its trial had ovarian damage, and children who took it had their growth plates widen.
On this page
- At the growth plate, members only
- Risks and side effects, members only
The rest of this page is for members
What has been measured, in whom, with every source, and what it does to the rest of you. And every article in the library.
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Educational content, not medical advice. Nothing here is a recommendation to take or stop taking anything — talk to a doctor about your own situation.