Palovarotene
Approved, for something elseHeight measured in peopleBy mouthSmall moleculeAlso Sohonos
A vitamin A-like drug built to hit one receptor subtype, approved for a rare disease in which bone forms inside soft tissue.
An orally bioavailable retinoic acid receptor agonist with particular selectivity for the gamma subtype. Through RARγ it decreases BMP/ALK2 signalling by inhibiting SMAD1/5/8 phosphorylation, reducing the chondrogenesis that produces heterotopic bone. Approved for reduction in the volume of new heterotopic ossification in fibrodysplasia ossificans progressiva, in adults and in children aged 8 and over for females and 10 and over for males; first approval was Canada, 21 January 2022.
Risks. It carries the strongest kind of label warning, for harm to a fetus and for closing a growing child's growth plates early, with x-rays and height checks required before and during treatment.
On this page
- At the growth plate, members only
- Risks and side effects, members only
The rest of this page is for members
What has been measured, in whom, with every source, and what it does to the rest of you. And every article in the library.
Join for $11.99Lifetime · 3 of 10 founding spots left
Tax is added at checkout (VAT/GST where it applies).
Renews every month at the current price plus tax until you cancel. Cancel from your account before the next monthly charge to stop it.
Card purchases are sold and charged by Link (Stripe) under Link's terms and refund policy.
Already a member? Sign in
Educational content, not medical advice. Nothing here is a recommendation to take or stop taking anything — talk to a doctor about your own situation.