Tideglusib
In human trialsMeasured in people, not heightBy mouthSmall moleculeAlso NP-12
A drug that permanently blocks GSK3, taken into human trials for brain diseases rather than for bone.
Thiadiazolidinone that inhibits GSK3β irreversibly and outside the ATP site. The GSK3 inhibitor taken furthest in controlled trials outside oncology, in brain conditions rather than bone.
Risks. In a trial in a rare brain disease, some people had short-lived liver blood-test rises and diarrhoea, and nothing is known about its safety for bone.
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