Meclizine

Inside the plate · In FGF and FGFR3

Chemical structure of Meclizine
Structure: Meclizine, PubChem CID 4034

Approved, for something elseHeight measured in peopleBy mouthSmall molecule

An old antihistamine that turns down part of the message from the receptor that slows cartilage growth, by a route nobody has worked out.

An antihistamine, raised here as a repurposing candidate rather than a drug developed for growth. How it acts on this pathway is unclear: it lowered ERK phosphorylation, but not MEK phosphorylation, in FGF-treated chondrocytes, and how it does so is not known.

PLOS One, 2013

Risks. It makes people drowsy enough that the label says not to drive on it, and it has never been established as safe in children.

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Educational content, not medical advice. Nothing here is a recommendation to take or stop taking anything — talk to a doctor about your own situation.