Diacerein
Approved, for something elseMeasured in people, not heightBy mouthSmall molecule
An osteoarthritis pill that blocks IL-1, approved in parts of Europe but not in America.
An anthraquinone converted in the body to rhein, which inhibits the production and the signalling of IL-1β. Approved for osteoarthritis in parts of Europe and elsewhere, and not approved in the United States.
Risks. European regulators restricted it after reports of diarrhoea, which affected up to half of patients in some trials, and liver injury.
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