Ciclosporin
Approved, for something elseMeasured in people, not heightBy mouthPeptideAlso Cyclosporine
A ring-shaped peptide from a fungus, taken by mouth, that switches off the enzyme controlling NFAT. A transplant medicine, also licensed for severe rheumatoid arthritis and severe psoriasis.
A cyclic peptide of eleven amino acids, produced by the fungus Beauveria nivea. It binds cyclophilin, and the complex inhibits calcineurin, the phosphatase that lets NFAT into the nucleus. Approved for prophylaxis of organ rejection in kidney, liver and heart allografts, and separately for severe active rheumatoid arthritis that has not responded to methotrexate and for severe recalcitrant plaque psoriasis in adults.
Risks. Its label carries the strongest class of warning there is: it should be prescribed only by doctors experienced with these medicines, it raises the risk of serious infection and of lymphoma and other cancers, and at ordinary doses it raises blood pressure and damages the kidneys, structurally and in proportion to how much and how long. No adequate controlled study has ever been completed in children, and it is not established as safe or effective below 18 for childhood arthritis or psoriasis.
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Educational content, not medical advice. Nothing here is a recommendation to take or stop taking anything — talk to a doctor about your own situation.