GSK3
The kinase that keeps β-catenin from accumulating, the compounds built to block it, and why switching off a hub enzyme is a different proposition from switching off a pathway.
The enzyme inside the destruction complex. It phosphorylates β-catenin so the cell destroys it as fast as it is made, and a Wnt signal works largely by taking GSK3 out of that job (see Wnt and β-catenin). Blocking GSK3 with a drug reaches the same endpoint from inside the cell, without needing a Wnt ligand.
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Educational content, not medical advice. Nothing here is a recommendation to take or stop taking anything — talk to a doctor about your own situation.