Wnt and β-catenin
The switch that converts cartilage into bone, the LRP5 and LRP6 co-receptors behind it, the contested claim that LRP5 acts on bone from the gut, why forcing it shortens a bone while lifting a brake lengthens one, and the drugs built for density against the one aimed at length.
Wnt signalling decides that a cell builds bone. It turns the cartilage template into the mineralised shaft, and osteoporosis drug development has spent two decades learning to push it. For height, it governs the conversion of cartilage to bone rather than the supply of new cartilage.
In this article
- LRP5 and LRP6
- Whether LRP5 acts through the gut
- At the growth plate
- Compounds
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Educational content, not medical advice. Nothing here is a recommendation to take or stop taking anything — talk to a doctor about your own situation.