GrowTallest

Retinoic acid

The other mechanism that closes a human growth plate, and the one where the exposure is almost always a drug: what retinoids do to cartilage, and what their labels require in children who are still growing.

HormonesUpdated

10 min read21 sources

Retinoic acid: vitamin A becomes retinoic acid, which binds an RAR and RXR pair on DNA. In a growth plate it lowers division and brings the swelling step forward, so the plate is spent and closes early. Vit ARARAR + RXRtarget genesRetinoic acidOn the genePlate spentfrom vitamin ARAR with RXRswells sooner

Two mechanisms are documented to shut a human growth plate. One is oestrogen, which does it as part of puberty (see Oestrogen). The other is retinoid excess, and the exposure is iatrogenic.

In this article

  • How the signal works
  • Why excess consumes the plate
  • Premature closure in people
  • What the labels require
  • Compounds
  • Summary

The rest of this article is for members

Join to read it, and every other article in the library.

Join for $11.99

Lifetime · 3 of 10 founding spots left

Tax is added at checkout (VAT/GST where it applies).

or $9.99 a month

Renews every month at the current price plus tax until you cancel. Cancel from your account before the next monthly charge to stop it.

Card purchases are sold and charged by Link (Stripe) under Link's terms and refund policy.

Educational content, not medical advice. Nothing here is a recommendation to take or stop taking anything — talk to a doctor about your own situation.