GrowTallest

Sirtuins and autophagy

The one pathway in this library where losing the signal measurably shortens a bone — and why the usual ways of pushing it, raising AMPK and inducing autophagy, point the other way.

Inside the cellUpdated

16 min read55 sources

One maturation sequence with two inputs from the same pathway. SIRT1 and autophagy support cartilage cells as they divide and swell, so losing either shortens the bone. Raising AMPK and inducing autophagy with a drug both inhibit mTORC1, which is what lets a cell enlarge, so they act as a brake on the same step. SIRT1, autophagylosing either shortens boneAMPK up, mTOR downcells enlarge lessDividingOne pathway, both waysSwellingin a plate with no bloodthen bone

Four things are usually bundled together here: NAD⁺, the fuel; SIRT1, the enzyme that runs on it; AMPK, the cell's fuel gauge; and autophagy, the clean-up system both of them switch on. They do belong together, and at a growth plate they do not all point the same way.

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