BMP and TGF-β
The two halves of one superfamily that push chondrocytes towards bone and hold them back, what happens in the disease where the push never stops, and the safety record of the drugs built from it.
BMPs and TGF-β are branches of the same family using the same kind of receptor and the same kind of messenger, and at the growth plate they pull against each other. BMPs push a chondrocyte towards hypertrophy and mineralisation. TGF-β and activin hold it back. The balance between them helps set the pace of the plate.
In this article
- When BMP signalling cannot switch off
- GDF5 and limb length
- Compounds
The rest of this article is for members
Join to read it, and every other article in the library.
Join for $11.99Lifetime · 3 of 10 founding spots left
Tax is added at checkout (VAT/GST where it applies).
Renews every month at the current price plus tax until you cancel. Cancel from your account before the next monthly charge to stop it.
Card purchases are sold and charged by Link (Stripe) under Link's terms and refund policy.
Already a member? Sign in
Educational content, not medical advice. Nothing here is a recommendation to take or stop taking anything — talk to a doctor about your own situation.