GrowTallest

NPR2

How NPR2, the receptor for C-type natriuretic peptide, drives bone growth at the growth plate, and the drugs that act on it.

Inside the plateUpdated

5 min read20 sources

CNP and NPR2: CNP binds NPR2, which makes cGMP and switches on PKGII. PKGII blocks RAF-1 in FGFR3's RAF-1, MEK, ERK chain, which lifts that brake on growth. CNPNPR2cGMPPKGIIFGFFGFR3RAF-1MEKERKdivide, swellCNP lifts the FGFR3 brake at RAF-1

Guanylyl cyclase-B, encoded by NPR2 on chromosome 9p13.3. The receptor for C-type natriuretic peptide.

In this article

  • Clearing CNP away
  • Compounds
  • cGMP elevation
  • Downstream of cGMP

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Educational content, not medical advice. Nothing here is a recommendation to take or stop taking anything — talk to a doctor about your own situation.