GrowTallest

FGF and FGFR3

How FGFR3 slows bone growth at the growth plate, and what happens when the receptor, its ligands or the cascade below it are blocked.

Inside the plateUpdated

6 min read28 sources

FGFR3: usually the receptor pairs and signals only when FGF binds, holding cell division back. In achondroplasia it signals with nothing bound, holds division back harder, and the bones come out shorter. FGFG380RUsualAchondroplasiasignals when FGF bindssignals with nothing bound

A brake on the growth plate. Most pathways in this library drive bone growth; this one restrains it, and nearly every agent aimed at it tries to release that restraint: at the receptor, at the FGF ligands that activate it, or at the cascade below it.

In this article

  • Mechanism
  • FGFR kinase inhibitors
  • Downstream pathway agents
  • Receptor blockade and degradation
  • Ligand trapping

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Educational content, not medical advice. Nothing here is a recommendation to take or stop taking anything — talk to a doctor about your own situation.