SOX9
The transcription factor that makes a cell a chondrocyte and keeps it one, the SOX5 and SOX6 partners it needs, what it switches on, and why it has to be switched off again for a bone to lengthen.
The master regulator of cartilage. It decides that a mesenchymal cell becomes a chondrocyte rather than anything else, then holds it in that identity and drives the matrix that gives cartilage its bulk. Almost every other pathway at the growth plate is adjusting a programme that SOX9 is running.
In this article
- SOX5 and SOX6
- Notch
- Acetylation and SIRT1
- MicroRNA control
- Compounds
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