Oestrogen
The hormone that closes growth plates in both sexes: the enzyme that makes it, the receptor it acts on, what blocking either one did in the trials, and what it cost in bone.
Oestrogen terminates longitudinal growth in both sexes. Aromatase, the product of CYP19A1, converts androgens to oestrogens; oestrogen acting through ERα drives the growth plate through terminal maturation and then fuses it. Much of testosterone's contribution to the pubertal growth spurt is therefore exerted after conversion. This step sets the duration available to every other pathway in this library.
In this article
- Men who cannot make oestrogen
- Aromatase inhibitor trials in boys
- Androgens acting directly
- Compounds: blocking the enzyme
- The receptor, and the drugs that bind it
- What "selective" means
- SERMs in bone
- Tamoxifen at a growing plate
- Compounds: binding the receptor
- Compounds: the androgen receptor
- Summary
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Educational content, not medical advice. Nothing here is a recommendation to take or stop taking anything — talk to a doctor about your own situation.