GrowTallest

Inflammation and growth failure

Why a child with long-running inflammation stops growing while growth hormone is still present and normal, and what happened to height when the drugs that switch that inflammation off were given to children.

HormonesUpdated

24 min read74 sources

Inflammation and growth failure: growth hormone is still present, but IL-6 raises SOCS3 inside the liver cell and TNF and IL-1 cut its growth hormone receptors, so less IGF-1 reaches the growth plate. GHnormalliver cellSOCS3IL-6 raises itTNF, IL-1 cut receptorsIGFlessSignal blockedLess IGF-1Slower growthGH is still thereout of the livershort while it lasts

This is the mirror image of Glucocorticoids. There a drug suppresses growth; here the illness does, and the drugs that remove it have been given to children with height measured.

In this article

  • IL-17
  • IL-10
  • Immune cells at bone
  • Complement
  • Where this is seen in children
  • A brake even without inflammation
  • Compounds
  • Summary

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