Cell shape and mechanical load
Why a cartilage cell that spreads out stops making cartilage, the cytoskeleton that enforces it, and the channels that turn pressure into a signal.
Chondrogenesis is marked by a tight dependence between cell shape, cytoskeletal organisation and the onset of cartilage gene expression. The cytoskeleton carries that dependence and acts on SOX9.
In this article
- Turning pressure into a signal
- Physical inputs
- Signalling between cells
- Compounds
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