JAK2, STAT5B and GH resistance
The step between the growth hormone receptor and hepatic IGF-1, the brake the same signal switches on, and why inflammation stops growth hormone working without lowering it.
Growth hormone binds its receptor and the liver makes IGF-1 (see Growth hormone and IGF-1 and IGF-1R). Between those two events sit a kinase and a transcription factor. Most of what goes wrong with growth hormone goes wrong here, not at either end.
In this article
- The off-switch
- Resistance without losing growth hormone
- When STAT5B fails
- Compounds
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Educational content, not medical advice. Nothing here is a recommendation to take or stop taking anything — talk to a doctor about your own situation.