Vitamin D and the VDR
What the receptor does for a growth plate, the experiment that separated it from mineral supply, the two enzymes that set how much active hormone exists, and what supplementing above sufficiency does to height in the trials.
The vitamin D receptor (VDR) is a nuclear receptor; its ligand is calcitriol, 1,25-dihydroxyvitamin D. Its function for the growth plate is systemic mineral supply — intestinal calcium and phosphate absorption — not signalling within the plate itself. Deficiency causes rickets and growth failure; the receptor's own activity at the plate is dispensable where minerals are adequate.
In this article
- The receptor that senses calcium
- Making the hormone and destroying it
- What supplementing does
- Compounds
- Too much vitamin D
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Educational content, not medical advice. Nothing here is a recommendation to take or stop taking anything — talk to a doctor about your own situation.