GrowTallest

Notch

Contact signalling that sets the timing of hypertrophy and the segmenting of the spine, and the vertebral and stature phenotypes when it goes wrong.

Inside the platePublished

9 min read35 sources

Notch passes only between cells that touch. Jagged on one cell frees NICD from the receptor on its neighbour, NICD binds RBPJ in the nucleus and flips it to an activator, and HES1 and HES5 come on and turn SOX9 down, which sets when the cell swells. NOTCHJaggedNICDnucleusNICDRBPJHES1, HES5SOX9Touching cellsNICD binds RBPJSOX9 downγ-secretase cutsRBPJ flips to activatorsets when it swells

Contact-dependent signalling. The ligand sits on one cell and the receptor on its neighbour, so the range is a single cell diameter and the output depends on which neighbour a cell has. NOTCH1 to NOTCH4, with ligands of the Jagged and Delta-like families.

In this article

  • What Notch does in the growth plate
  • Somitogenesis and the segmentation clock
  • Alagille syndrome
  • Hajdu-Cheney syndrome
  • RUNX2
  • Compounds

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