GrowTallest

METTL3 and m6A

The chemical mark that decides which messages a cell keeps, the two transcripts it removes in cartilage, and the compounds that raise it.

Inside the cellUpdated

7 min read19 sources

METTL3 writes the m6A mark on a transcript, YTHDF2 reads it and the transcript decays early. Less Fem1b spares GLI1; less Lats1 frees YAP. METTL3/14YTHDF2Fem1b ↓GLI1 ↑Lats1 ↓YAP ↑WriterReaderWhat is removedMETTL3 adds m6AYTHDF2, then decayquiescence, proliferation

N6-methyladenosine (m6A) is the commonest internal modification on messenger RNA. METTL3 is the catalytic subunit of the writer complex it is installed by, working with METTL14 and WTAP. The mark is a layer of control above transcription: the gene is read as usual, and m6A then decides how long the transcript survives.

In this article

  • Holding skeletal stem cells quiescent
  • Cartilage and mechanical load
  • The overgrowth syndromes
  • Compounds

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