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Matrix proteins beyond collagen

The non-collagen proteins of cartilage and bone matrix, the dysplasias their mutations cause, and which of them changes the length of a bone.

Matrix and bonePublished

10 min read44 sources

Matrix proteins beyond collagen: a mouse with no COMP at all is normal. A faulty copy that is made jams inside the chondrocyte instead of reaching the matrix, the growth plate loses cells, and the bone comes out short. none mademade, faultyProteinChondrocyteBonenone or faultyjams insidefewer cells, shorter

The structural proteins that are not collagen and not aggrecan: the adaptors that hold the fibre network in register, and the SIBLING phosphoproteins that decide where mineral forms. Collagen and its folding diseases are in Collagen and ER stress; the swelling gel in Aggrecan and matrix sulfation.

In this article

  • COMP
  • Matrilin-3
  • Perlecan
  • SPARC
  • The SIBLING proteins
  • MMPs and the TIMP brake
  • Fibronectin and fibrillin

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